pawanramamali.r-universe.dev

[pawanramamali] edgemodelr 0.4.1

prm@outlook.in (Pawan Rama Mali) — Tue, 26 May 2026 10:28:56 GMT

Enables R users to run large language models locally using 'GGUF' model files and the 'llama.cpp' inference engine. Provides a complete R interface for loading models, generating text completions, extracting vector representations, and streaming responses in real-time. Includes grammar-constrained generation for structured output, text classification, and retrieval-augmented generation (RAG) pipelines. Supports local inference without requiring cloud APIs or internet connectivity, ensuring complete data privacy and control. Based on the 'llama.cpp' project by Georgi Gerganov (2023) .

[r4sub] r4sub 0.1.0

prm@outlook.in (Pawan Rama Mali) — Tue, 17 Mar 2026 06:06:54 GMT

The 'r4sub' package is a meta-package that installs and loads core packages of the R4SUB (R for Regulatory Submission) clinical submission readiness ecosystem. Loading 'r4sub' attaches 'r4subcore', 'r4subtrace', 'r4subscore', 'r4subrisk', 'r4subdata', and 'r4subprofile'.

[r4sub] r4subtrace 0.1.1

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:28:18 GMT

Quantifies and explains end-to-end traceability between clinical submission artifacts (ADaM (Analysis Data Model) outputs, derivations, SDTM (Study Data Tabulation Model) sources, specs, code). Builds trace models from metadata and mapping sheets, computes trace levels, and emits standardized R4SUB (R for Regulatory Submission) evidence table rows via 'r4subcore'.

[r4sub] r4subscore 0.1.1

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:28:06 GMT

Converts standardized R4SUB (R for Regulatory Submission) evidence into indicator scores, pillar scores, and a Submission Confidence Index (SCI). Provides sensitivity analysis, explainability tables, and decision band classification to answer the question: are we ready for regulatory submission.

[r4sub] r4subrisk 0.1.1

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:27:50 GMT

Quantifies submission risk using a Failure Modes and Effects Analysis (FMEA)-inspired framework (probability, impact, detectability). Builds risk registers from evidence, computes Risk Priority Numbers (RPN), classifies risk levels, and emits standardized R4SUB (R for Regulatory Submission) evidence table rows via 'r4subcore'. Supports risk mitigation tracking and trend analysis across submission milestones.

[r4sub] r4subprofile 0.1.1

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:27:35 GMT

Defines submission profiles per regulatory authority with authority-specific pillar weights, decision thresholds, indicator requirements, and risk configuration. Supports the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA), Pharmaceuticals and Medical Devices Agency (PMDA), Health Canada, Therapeutic Goods Administration (TGA), and Medicines and Healthcare products Regulatory Agency (MHRA). Integrates with 'r4subscore' and 'r4subrisk' configuration systems.

[r4sub] r4subdata 0.1.2

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:21:23 GMT

Provides realistic synthetic example datasets for the R4SUB (R for Regulatory Submission) ecosystem. Includes a pharma study evidence table, ADaM (Analysis Data Model) and SDTM (Study Data Tabulation Model) metadata following CDISC (Clinical Data Interchange Standards Consortium) conventions (), traceability mappings, a risk register based on ICH (International Council for Harmonisation) Q9 quality risk management principles (), and regulatory indicator definitions. Designed for demos, vignettes, and package testing.

[r4sub] r4subcore 0.1.2

prm@outlook.in (Pawan Rama Mali) — Mon, 16 Mar 2026 11:21:19 GMT

Foundational package in the R4SUB (R for Regulatory Submission) ecosystem. Defines the core evidence table schema, parsers, indicator abstractions, and scoring primitives needed to quantify clinical submission readiness. Provides a standardized contract for ingesting heterogeneous sources (validation outputs, metadata, traceability) into a single evidence framework.

[pawanramamali] shinypayload 0.3.0

prm@outlook.in (Pawan Rama Mali) — Mon, 26 Jan 2026 15:53:23 GMT

Handle POST requests on a custom path (e.g., /ingress) inside the same 'shiny' HTTP server using user interface functions and HTTP responses. Expose latest payload as a reactive and provide helpers for query parameters.